Pluto is John Irvings chart ruler and therefore has a prior position in his chart, which we can see very impressing in the transits. We can see transitting Pluto forming an aspect to a natal planet, every time John Irving made one of the major achievements in his career.
Pluto is the planet of transformation, destroying the old in order to make way for something new.
Uranus is always calling for a change.
The City of Vienna must have influenced Irving deeply, as she is mentioned in almost all of his novels. Here in Vienna Irving had the idea for his first novel “Setting Free the Bears”.
Irving´s time in Vienna in the early 1960´s was accompanied by transitting Pluto opposing his natal Sun. Pluto then wanted Irving to deal with questions of identity and self-assertion.
Irving´s breakthrough as a writer came in 1978 with his third novel „The World According to Garp“. Transitting Pluto trining his natal Mercury meant a huge turning point (Pluto), as from now on Irving could earn his living from writing (Mercury).
Transitting Uranus was then squaring his natal Mercury: the sudden breakthrough (Uranus), and Irving became well-known to the broad public with his writing (Mercury as the ruler of the 10th house).
In 2000 Irving won the Oscar for the screenplay he wrote, based on his novel „The Cider House Rules“.
Once again transitting Pluto was one of the major aspects, squaring his natal sun, calling for self-assertion once again after he had distanced himself from the film adaption of his novel “Owen Meany”.
And of course Uranus again: Transitting Uranus conjunct his natal Mercury helped Irving to find a new way of writing, because writing a screenplay needs a different approach than writing a novel – maybe this was kind of a writing-experiment (Mercury-Uranus) for him.